عوامل خطر در صرع در کودکان با سابقه هیپوگلیسمی نوزادی

Meisam Babaei, MD © ℗, Dorsa Vagharmoosavi, MD, Shima Hoseinzadeh, MD, Rezvan Rajabzadeh, PhD

عوامل خطر در صرع در کودکان با سابقه هیپوگلیسمی نوزادی

کد: G-1010

نویسندگان: Meisam Babaei, MD © ℗, Dorsa Vagharmoosavi, MD, Shima Hoseinzadeh, MD, Rezvan Rajabzadeh, PhD

زمان بندی: زمان بندی نشده!

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خلاصه مقاله

Introduction: Neonatal hypoglycemia remains one of the important causes of brain damage in infants which can leads to long-term neurological disabilities, including epilepsy. In the present study, we examined the risk factors of epilepsy in children with a history of neonatal hypoglycemia. Materials and Methods: this is a cross-sectional case control study which was done after obtaining ethical code REC.NKUMS.IR.1401.070 in records of hospitalized neonates between September 2016 to September 2021. From total of 422 records with initial diagnosis of hypoglycemia, and based on entry and exit criteria, 109 records were included in the study. Then a standardized questionnaire, based on history and examination and also age and stage questionnaire (ASQ) test completed. Finally, the data was analyzed based on SPSS version 20 software and statistical analytic tests. Results: out of 422 documents, only 233 documents had recorded and confirmed hypoglycamia and were included in the study. Of these, 124 cases were excluded due to lack of patients access or not interested to participating in the study. Ultimately, 109 patients were included for history taking and neurologic examination and completed ASQ test, and also divided into epileptic(case) and non-epileptic(control) groups. (19 patients (17%) in case, and 90 patients (82%) in control group). The results of this study showed, neonatal age at the time of hypoglycemia, duration of hypoglycemia, duration of staying in hospital, concomitant seizures, family history of epilepsy, and developmental disabilities, had statistically significant difference between two groups. (P0/05) based on logistic regression analysis, the most important risk factors for epilepsy in children with previous history of hypoglycemia in neonatal period were include: neonatal age at the time of hypoglycemia, duration of hypoglycemia, family history of epilepsy and duration of hospitalization. Conclusion: those results showed that, continuous maternal education by health care providers particularly around the birth period, can effectively prevent many of these consequences. Keywords: risk factor, neonatal hypoglycemia, epilepsy

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